Description
Compounded Tretinoin & Niacinamide Cream
Tretinoin is widely celebrated as the gold standard in dermatology for anti-aging and skin renewal, but its potent cellular turnover effects can sometimes cause dryness, redness, and irritation. By compounding Tretinoin with Niacinamide (Vitamin B3), we create a synergistic, dual-action topical formulation that maximizes skin benefits while minimizing the common side effects of retinoid therapy.
Our Compounded Tretinoin & Niacinamide Cream is a non-sterile, custom-prepared dermatological treatment. This combination is highly effective for patients looking to address fine lines, uneven skin tone, hyperpigmentation, and acne, offering a smoother and more tolerable path to radiant skin.
Our compounding pharmacy formulates this non-sterile topical cream using pharmaceutical-grade ingredients tailored to your dermatologist’s exact specifications.
Active Ingredient 1: Tretinoin (customized percentage, typically ranging from 0.018% to 0.1%).
Active Ingredient 2: Niacinamide (typically formulated at 4% to 5%, depending on the prescription).
Dosage Form: A soothing, dermatologically optimized topical cream base.
Quality Commitment: Prepared in our compounding laboratory under strict quality control standards, ensuring a stable, homogenous blend for even application.
The power of this compound lies in how the two ingredients complement one another:
Tretinoin: Binds to retinoic acid receptors to accelerate skin cell turnover, clear pores, and stimulate the production of collagen and elastin. This smooths wrinkles and fades dark spots over time.
Niacinamide: Acts as a powerful anti-inflammatory and barrier-repairing agent. It helps increase the skin’s natural ceramide production, retaining moisture and significantly reducing the redness and peeling often caused by Tretinoin. Additionally, Niacinamide blocks the transfer of pigment to skin cells, further brightening the complexion.
To achieve the best results while protecting your skin’s health, follow these guidelines and your provider’s instructions:
Nighttime Application Only: Tretinoin breaks down when exposed to sunlight. Apply this cream only at night to a clean, completely dry face.
Sun Protection is Essential: This formulation increases your skin’s sensitivity to UV rays. You must apply a broad-spectrum sunscreen (SPF 30 or higher) every morning, even on cloudy days.
Pregnancy Warning: Tretinoin should not be used by individuals who are pregnant, planning to become pregnant, or nursing.
Gradual Introduction: Even with the soothing addition of Niacinamide, your provider may recommend starting usage slowly (e.g., every other night) to allow your skin to acclimate.
Why combine Tretinoin with Niacinamide instead of using them separately?
Combining them into a single compounded cream simplifies your nighttime routine and ensures both active ingredients are delivered in a stable, compatible base. The Niacinamide actively works to calm the skin and protect the moisture barrier simultaneously as the Tretinoin works to renew the skin cells.
Is this a sterile preparation?
No. This is a non-sterile compounded preparation intended strictly for topical dermatological use on intact skin, prepared safely following standard pharmacy compounding guidelines.
Do you ship this custom cream outside of Texas?
No. To strictly adhere to our state pharmacy licensing, we fulfill and ship all compounded skincare prescriptions exclusively to patient addresses located within the state of Texas.

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